what is tren

Tadalafil is a reversible, selective inhibitor of specific phosphodiesterase ) is a cyclic guanosine monophosphate (cGMP). When sexual stimulation causes local release of nitric oxide, inhibition  tadalafil leads to higher concentrations of cGMP in the corpus cavernosum of the penis. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis that causes erections. Tadalafil has no effect in the absence of sexual stimulation.

Studies in vitro have shown that tadalafil is a selective inhibitor  is an enzyme found in corpus cavernosum smooth muscle in vascular smooth muscles of inner organs, skeletal muscle, platelets, kidneys, lungs and cerebellum. Effects of tadalafil  is more active than other phosphodiesterase. Tadalafil what is tren is 10 000 times more potent against  than against, which are located in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle and in other organs. Tadalafil 10 000 times more active blocks what is tren enzyme that is found in the heart and blood vessels. This selectivity as compareds significant, is an enzyme participating in the reduction of the heart muscle. Additionally, tadalafil is approximately 700 times more active against  found in the retina and is responsible for fotoperedachu. Tadalafil also shows effect in 9000-fold more potent compared with its effect   times more potent  compared.

Tissue distribution and physiological effects ingibirovanpya has not yet been elucidated.

Tadalafil improves erection and increases the possibility of full sexual intercourse.

Tadalafil in healthy individuals does not cause significant changes in systolic and diastolic blood pressure compared with placebo in the prone position . Tadalafil does not cause significant changes in heart rate. Tadalafil does not cause changes in the recognition of colors (blue / green), due to its low affinity . Furthermore, there is no effect on visual acuity tadalafil, elektrorstinogrammu intraocular pressure and pupil size.

In order to evaluate the effect of the daily administration of tadalafil on spermatogenesis few studies have been conducted. None of studies have observed undesired effects on sperm morphology and motility. In one study showed a reduction in the average sperm concentration as compared to placebo. Reducing Occupational sperm it was associated with a higher frequency of ejaculation. Furthermore, there was no adverse effect on the average concentration of the sex hormones, testosterone, luteinizing hormone and hormone follikulostimuliruyushego when taking , compared to placebo.

The efficacy and safety what is trenwas studied in clinical trials. Improved erections were observed in patients with erectile dysfunction of all severities when receiving tadalafil once daily. The primary efficacy studies, the use of tadalafil 5 mg, 62% and 69% of attempts at sexual intercourse were successful compared to 34% and 39% of patients taking placebo. Receiving 5 mg tadalafil significantly improved erectile function for 24 hours between doses.

 

Absorption
After oral administration of tadalafil is rapidly absorbed. The average maximum concentration what is tren) in the plasma is attained, on average over 2 hours after ingestion.
The rate and extent of absorption of tadalafil is not dependent on receiving write, and the can be used regardless of the reception of write.
Hours (morning or evening) are not had no clinically significant effect on the rate and extent of absorption.
Pharmacokinetics tadalafil in healthy individuals is linear with respect to time and dose. In the dose range from 2.5 to 20 mg of the area under the curve “concentration-time» what is tren increases proportionally with dose. Equilibrium plasma concentrations are reached within 5 days while taking the drug once a day.
The pharmacokinetics of tadalafil in patients with erectile dysfunction is similar farmakokpnetike drug in patients without erectile dysfunction.

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