Tren hexahydrobenzylcarbonate should be used with caution in patients with a predisposition to priapism (for sickle cell anemia, multiple myeloma, leukemia IPT) or in patients with anatomical deformation of the penis (angulation, cavernous fibrosis or Peyronie’s disease). You should also be careful while reception with potent inhibitors of isoenzyme (ritonavir sakvinavnr, ketoconazole, itraconazole, erythromycin), antihypertensives.
Dosing and Administration
For oral administration.
For patients with frequent sexual activity (more than two times per week) recommended frequency of reception – daily, once a day, 5 mg, in one and the same time, regardless of the meal. The daily dose can be reduced to 2.5 mg depending on individual sensitivity.
For patients with infrequent sexual activity (at least twice a week)
recommended the appointment at a dose of 20 mg, just prior to sexual activity, according to the medical use of the drug instructions .
Adverse events associated with taking tadalafil, are usually minor or moderate in severity, transient and diminished with continued use of the drug. The most common adverse events were headache and dyspepsia, and back pain, myalgia, “tides” of blood to the face, nasal congestion.
Violations of the cardiovascular system : Uncommon : palpitations ¹, tahikardiya¹, reduction in blood pressure (in patients who are already taking antihypertensive agents), increased blood pressure Rare myocardial infarction ¹ Unknown (impossible to estimate the frequency of responses from the available data): unstable angina ¹
Violations by the organs of vision: Uncommon : violation of the visual fields is not known (it is impossible to estimate the frequency of occurrence of the reactions from the available data ): nearterialnaya anterior ischemic optic neuropathy, optic nerve, retinal vein occlusion
Disorders of the respiratory system: Uncommon (> 0.1%, <1%): epistaxis
Violations of the skin and subcutaneous tissue: Uncommon : rash, urticaria, hyperhidrosis (excessive sweating), not known (can not be to evaluate the frequency of responses from the available data): Stevens-Johnson syndrome, and exfoliative dermatitis
General disorders: Uncommon tren hexahydrobenzylcarbonate): otek persons unknown (it is impossible to estimate the frequency of occurrence of the reactions from the available data):sudden cardiac death ¹
Violations of the immune system: Uncommon : hypersensitivity reactions
Violations of the reproductive system: Rare: prolonged erection is not known (it is impossible to estimate the frequency of occurrence of the reactions from the available data): priapism
¹ observed in patients who previously have cardiovascular risk factors.
However, it is impossible to pinpoint whether these phenomena directly with these risk factors, with tadalafil, to sexual arousal, or a combination of these or other factors.
With single assignment healthy tren hexahydrobenzylcarbonate persons tadalafil in a dose of 500 mg and patients with erectile dysfunction – repeatedly to 100 mg / day, adverse effects were the same as in the application of lower doses. In case of overdose should be carried out standard symptomatic treatment. In hemodialysis tadalafil virtually displayed. steroidi italia