Trenbolone side effects a derivative of benzodiazepine sedative-hypnotic, anticonvulsant and central muscle relaxant effect.
The mechanism of action of diazepam is due to stimulation of benzodiazepine receptors supramolecular benzodiazepine-receptor complex hlorionofor leading to increased inhibitory effect (gamma-aminobutyric acid – neurotransmitter pre- and postsynaptic braking in all departments of the central nervous system) in the transmission of nerve impulses. Stimulates benzodiazepine receptors located in the allosteric center of postsynaptic receptors ascending activating reticular formation of the brain stem and neurons of lateral spinal cord horns, reduces the excitability of the subcortical structures of the brain (the limbic system, thalamus, hypothalamus), inhibits polisinapticheskie spinal reflexes.
The anxiolytic effect is due to the influence of in the amygdala of the limbic system and manifests itself in the reduction of emotional stress, easing anxiety, fear, anxiety.
The sedative effect is due to the influence on the reticular formation of the brain stem and the nonspecific thalamic nuclei and manifested a decrease in symptoms of neurotic origin (anxiety, fear).
The main mechanism of hypnotic action is in the oppression of the cells of the reticular formation of the brain.
Anticonvulsant action is realized by increasing presynaptic inhibition. It suppressed the spread of epileptogenic activity, but not removed the excited state of the hearth.
The central muscle relaxant effect is due to inhibition of polysynaptic spinal afferent inhibitory ways (to a lesser extent and monosynaptic). Perhaps, and direct inhibition of motor nerve and muscle function.
With moderate sympatholytic activity, may cause blood pressure reduction and expansion of the coronary vessels. Increases pain threshold. Suppresses sympathadrenalic and parasympathetic (including vestibular) paroxysms. Reduces nocturnal gastric acid secretion.
The action of the drug is observed to the 2-7 day of treatment.
In the productive psychotic symptoms genesis (acute delusional, hallucinatory, affective disorders) has practically no effect, it is rarely observed decrease in affective intensity, delusional disorders.
In the withdrawal syndrome in chronic alcoholism causes weakening of agitation, tremor, negativism, and delirium tremens and hallucinations.
The therapeutic effect trenbolone side effects in patients cardialgia, arrhythmias and paresthesias observed at the end of 1 week.
Absorption high. Once inside it absorbed about 75%. Clinical effects occur in half an hour after administration and the maximum concentration (C max ) achieved in the plasma at 2 hours, the equilibrium concentration (C ss ) for a constant reception achieved in 1-2 weeks. Diazepam operates for a long time of about 12 hours Bioavailability -. 90%. Binding to plasma proteins is 94-99%, and usually higher in men than in women.
Diazepam and its metabolites penetrate the blood-brain and the placental barrier are found in human milk in concentrations corresponding to 1/10 part of plasma concentrations. Relationship to plasma proteins -. 98%
is metabolized in the liver with the participation isozymes . 98-99% to pharmacologically highly active derivative (desmetildiazepam) or less active (temazepam and oxazepam)
excreted by the kidneys – 70% (in the form of glucuronides), in an unmodifiedthe feces. Excretion is biphasic: for the initial and rapid distribution of the active phase should be prolonged phase desmetildiazepama – 30-100 hours, temazepam.
If you re-use the accumulation of diazepam and its active metabolites significant. Refers to benzodiazepines with a long trenbolone side effects , excretion after cessation of treatment – slow because metabolites retained in blood for several days or even weeks.